Snezna Rogelj, PhD

Professor

Biology

snezna.rogelj@hghgjm.com
575 - 835 - 5608
Jones Annex 315
Fall 2020 office hours by phone - Tues & Thurs 5-6 pm, Fri 4-5 pm

Education

Ph.D. Biochemistry, 1985 Dissertation: Action of Retinoic Acid and cAMP in the
Differentiation of F9 Teratocarcinoma and B16-F1 Melanoma Cell Lines

Boston University School of Medicine
Summer Physiology Course at Woods Hole Marine Biological Laboratory, 1982
B.S. Physics with Emphasis on Astronomy, 1976, Ohio State University

Dissertation: Action of Retinoic Acid and cAMP in the Differentiation of F9 Teratocarcinoma and B16-F1 Melanoma Cell Lines

Honors

U.S. Department of Energy's Defense Programs Early Career Scientist and Engineer Award. 1999.

Outstanding New Mexico Tech Professor, 2009

NMT Distinguished Research Award, 2017

Experience

Research Assistant Professor of Pathology, University of New Mexico Medical School 1/97 to 6/98) and Research Associate, Department of Pathology at UNM Medical School (93-96). Molecular mechanisms of leukocyte target recognition in the human immune and inflammatory responses.
Scientist, ASTRA Biomedical Research Center, Bangalore, India (1989-1992). Parasitology: Developed a cell-line from the tapeworm Taenia Solium. Heterologous gene expression in yeast and mammalian cells
Lecturer, Harvard Medical School, Children's Hospital, Boston, MA. Department of Surgical Research, (1988-1989). Role of growth-factors in tumorigenesis, neovascularization, and the metastatic spread of tumors.
Post-Doctoral Fellow, Whitehead Institute at MIT, Cambridge, MA. (1984-1988). Molecular and cell biology of growth factors in cancer. Participated in the cloning of the first anti-oncogene. Graduate Research Assistant, Department of Biochemisty, Boston University School of Medicine, (1979-1984).

Technician, Honeywell-Avionics Division in Minniapolis, Minnasota, January-August 1979.

Research Assistant, Hematology Department, Ohio State University, Columbus, OH. (1976-1979)

Teaching Assistant, Astronomy Department, Ohio State University, Columbus, OH. (1974-1976).

MS or PhD Graduates from the Rogelj Lab

Manuel Adrian Rubio, MS (2002): Functional Equivalence of Selected Pesticides and Non-Steroidal Anti-Inflammatory Prescription Drugs.
Amy Michelle Garcia, MS (2002): Mercury Modulates Human Immune Function by Altering the Expression of Leukocyte Adhesion Molecules.
Karen Cooper, MS (2002): Immunosuppression by Environmental Pollutants via the Loss of L-Selectin.
Huining Liang, MS (2002): Development of Immuno-PCR Methodologies for High Sensitivity Detection of Pathogenic Proteins.
Catrina Huff, MS (2003): The Development of a Novel Biosensor for Rapid Detection of Calmodulin Inhibition by Pesticides and Pharmaceutical Drugs.
Kate Shapland, MS (ABD 2004): Development of Aptamer DNA Methodologies for High Sensitivity Detection of L-selectin Protein./ Signaling Pathways that Lead to the THC-Mediated L-Selectin Shedding.
Caroline Maynard, MS (2004): Effect of Selected Pharmaceutical Drugs and Environmental Pesticides on Cyclooxygenase I & II activity.
Kimbery Reiter, Medical Student at UNM; completed Medical School Research Project "Tamoxifen Promotes Leukocyte L-selectin Shedding in an Activation- and Calcium-Independent Manner", (2004).
Michele Denton, MS (2005): Development of a DNA Tag library for Use in Single-primer Pair, Multiplex PCR Immuno-detection System.
Nicola Maynard, MS (2005): Development of a Bead-Based Assay with the Capability of Detecting Calmodulin-Binding Compounds via Flow Cytometry.
Artem Kireev, MS (2005): Synthesis and Comparative Biological Evaluation of Structurally Simplified Analogues of Selected Amaryllydaceae Alkaloids with Potent Anticancer and Antiviral Activities.
Troylyn Zimmerly, MS (2005): Immuno-PCR Detection of Escerichia coli 0157:H7 and Campylobacter jejuni. Commercial Preparations of Bacitracin are Contaminated with DNase.
Satya Sai Vaddadhi,, MS (2005, M.S. Mathematics): Effects of Xenobiotic Body Burden on Human Health.
Kai Shen, MS (2006): Identification of Vaccine-binding Peptides via the Phage Display Technology.
Tommie McSherry, MS (2006): Biochemical Characterization and Isolation of Degradative Enzymes in Bacitracin.
Marisol Gonzales,, MS (ABD 2006): Induction of Apoptosis by Tetrahydrocannabinol and Tamoxifen.
Qiu Jin, MS (2008): Isolation of Vaccinia-binding Peptides using Phage Display Technique.
Ray Brungard, MS (2008): Improving Hydrophobic Drug Dispersion and Stability using Surfactant-free Suspensions.
Felicia Navarro, MS (2009) : Investigation of Indone-azo Structural Analogs for Growth Inhibition of Multi-Drug Resistant Staphyloccus aureus.
Amy Baker-Kireev, MS (2009): "Cellular Stress Response to Titanium Dioxide Nanoparticles.
Vineet Patel, MS (2009): Isolation and Characterization of Peptides Binding to Influenza Vaccine Using Phage Display.
Seth Daly, MS (2010) Antibacterial and Synergistic Activity of Substituted Indoles Against Methicillin-Resistant Staphylococcus aureus.
Indranil Malik, MS (2011) Identification and Characterization of a Novel Antimicrobial Agent Against Drug-resistant Bacteria.
Robert Johnston, MS (2011) The Anti-proliferative Effects of the Natural Compound ZR2.
Amanda Thomas Peretti, MS (2012): Novel Podophyllotoxin Analogues: Screening for Toxicity and Modes of Anti-Cancer Activity.
Paul Bianchi, MS (2012): The mechanism of action and downstream effects of a novel anti-cancer drug Rigidin 8.
Alexander Mikhalen, MS (2012): Synthesis and Evaluation of Fatty Acid-Containing Heterocyclic Analogues of Podophyllotoxin for Use in Liposomal Drug Delivery Systems.
Anntherese Romero, MS (2013): Investigation of Natural Product Analogues as New Anticancer Agents.
Gina Nguyen, MS (2013): Drug-induced Growth Inhibition of Human Glioblastoma.
Les Edwards, MS (2013): Combination Antimicrobial Therapy: In vitro photodynamic therapeutic and synergistic activity of novel drug candidates.
Cody Champion, MS (2014): Photodynamic Anti-MRSA Activity of Modified Indoles.
Temilade Cecelia Ogunro, MS (2014): Effect of Temperature and Ergosterol Content on Batrachochytrium dendrobatidis, MS (Bd) Viability.
Alex Pendleton, MS (2016): Normalization, Differentiation, and Growth Arrest of Glioblastoma Cells by a Small, Novel Anticancer Molecule AKS7.
Danielle Turner, MS (2016): Drug Discovery for Chagas Disease.
Marie Johnson, MS (2017): Bioremediation of the Peroxide Explosive Methyl, Ethyl Ketone Peroxide by Horseradish Peroxidase., MS (Rogelj academic advisor, Paul Calvert, MS (MatE) research advisor)
James Horne, MS (2017): Experimental and Computational Meta-transcriptomic Tools towards Medical and Environmental Applications. (Rogelj academic advisor, Patrick Chain, MS (LANL) research advisor)
Talysa Ogas, MS (2017): In vitro characterization of the mechanisms of action of a small novel hydroxamic acid compound in Glioblastoma Multiforme.
Shishir Acharya , MS (2017): A Study of Environmental Pollutants' and Anti-Candida and Anti-Beta-lactamase Drugs' Toxicities.
Liam Hallada MS (2018) Proteasome Inhibition. Chemistry research co-advisor Dr. Tello-Aburto.
Haley Campos, MS (2019): Protective Properties of Cytoplasmic Abundant Heat Soluble 3 Protein. Research co-advisor Dr. DeVeaux.
Joseph Couls, MS-current: Transcriptomic Response of T. cruzi-infected Human Cells to AKS7-mediated Cure.
Danielle Turner, PhD BioTechnology (2019): Discovery and Development of Antimicrobial Agents Targeting Multi-drug Resistant Bacterial, Fungal, and Parasitic Pathogens: From the Bench to the Bedside.

Masters of Science Teaching Degrees

Thesis Committee Member or Co-Advisor

Bridget Rutz (M.S. Biology, advisor Dr. Kieft)
Justin Tibbitts (M.S. Biology, advisor Dr. Kirk)
Sandy Dunaway (M.S. Biology, advisor Dr. Smoake)
Joseph Pierce (M.S. Biology, advisor Dr. Smoake)
Margaret-gail Medina (Ph.D. Materials Eng.advisor Dr. Bond)
F. Arzum Simsek (Ph.D. Materials Eng. advisor Dr. Bond)
Rebekkah Silva (M.S. Biology, advisor Dr. Kieft)
Zhu Fu (M.S. Biology, advisor Dr. Kieft)
Bridget Rutz (M.S. Biology, advisor Dr. Kieft)
Sandy Dunaway (M.S. Biology, advisor Dr. Smoake)
Susan Velarde (M.S. Biology, advisor Dr. Smoake)
Misty Millison (M.S. Biology, M.S. advisor Dr. Kieft)
Nikki Beauchamp (M.S. Biology, advisor Dr. Shors)
Hiashi Cao (Ph.D in Chemistry,, advisor Dr. Heagy)
Madhuri Manpadi (Ph.D in Chemistry,, advisor Dr. Kornienko)
Severine Van Slambrouck (Ph.D. in Chemistry, advisor Dr. Steelant)
Amanda Bernauer (M.S. Biology, advisor Dr. Kieft)
Angela Dickey (M.S. Chemistry, advisor Dr. Pullin)
Yujie Jin (M.S. Environmental Engineering advisor Dr. Huang)
Tamara Hartenberger, (M.S. Biology, advisor Dr. Shors)
Jeff Bogzevitz (MST Biology, advisor Dr. Shors)
Ernest Yufenyuy (M.S. Biology, advisor Dr. Kieft)
Jerimiah (Jeb) Robinson, (M.S. Materials advisor Dr. Majumdar)
Artem Kireev (Ph.D. Chemistry, advisor Dr. Kornienko)
Manoj Kumar (Ph.D. in Chemistry, advisor Dr. Zhang)
Giovanni Luchetti (Ph.D. in Chemistry, advisor Dr. Kornienko)
Yanyan Guo (Ph.D. candidate in Chemistry, advisor Dr. Zhang)
Nikolai Edvokimov (Ph.D. in Chemistry, advisor Dr. Kornienko)
Jacy Gansz (MS in Materials, advisor Dr. Tartis)
Elizabeth Larkin (MS in Materials, advisor Dr. Tartis)
Alexander Mikhalin (MS in Biology, advisor Dr. Tartis)
Ranjith Kumar Meka (PhD in Chemistry, advisor Dr. Heagy)
Anntherese Romero (MS in Biology, advisor Dr. Magedov)
Margaret Snell (MS in Mathematics, advisor Dr. Hossain)
Robert Johnston (PhD in Materials Engineering, advisor Dr. Tartis)
Alex Kent (PhD in Computer Science and Engineering, advisor Dr. Liebrock)
Shawn Henry (MS in Chemistry, advisor Dr. Frolova)
Patrick Illescas (MS in Biology, advisor Dr. Reiss)
Karen Simmons (MS in Biology, advisor Dr. Kieft)
Olivia Chavez (MS in Biology, advisor Dr. Kieft)
Rubi Gurung (PhD in Chemistry, advisor Dr. Piyasena)
Gayatri Gautam (PhD in Chemistry, advisor Dr. Piyasena)
Ashley Chavez (MS in Biology, advisor Dr. DeVeaux)
Liam Hallada (MS in Biology, Chemistry research advisor Dr. Tello-Aburto)
Bradley Stevens (MS in Biology, Chemistry research advisor Dr. Tello-Aburto)
Primal Silva (MS in Biology, Neuroscience research advisor Dr. Thompson)
Ethan Contreras (MS in Biology, Neuroscience research advisor Dr. Thompson)
Betty Fish (MS candidate in Biology, Neuroscience research advisor Dr. Thompson)
Ankita Schwarting (MS candidate in Biology, Neuroscience research advisor Dr. Thompson)
Nelum Perera (PhD candidate in Chemistry, advisor Menake Piyasena)

Rogelj Post-Doctoral Research Associates

Dr. Hongkuan Fan (2001-2002)
Dr. Hong Tang ( 2004-2009)
Dr. Megha Khandelwal (2016-2017)
Dr. Danielle Turner (2019-2021)

Rogelj Patents

Patents

Methods for treatment of resistant cancer

Patent number: 10414778

Abstract: The present disclosure describes a method to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds of the invention can decrease the rate of proliferation of drug-resistant cancer cells, such as glioma, lung cancer, and uterine sarcoma.

Inventors: Snežna Rogelj, Liliya Frolova, Alexander Kornienko, Sean Henry

Antibiotic sensitivity-restoring and photosensitive agents

Patent number: 10239834

Abstract: The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.

Inventors: Snežna Rogelj, Liliya Frolova, Alexander Kornienko, Leslie D. Edwards, Cody Champion, Kailee Zingler, Danielle Nicole Turner

Frankiamicin A compositions and methods

Patent number: 10010558

Abstract: In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating a subject having, or at risk of having, a condition caused by a microbial infection treatable with frankiamicin A. Generally, the method includes administering to the subject an amount of frankiamicin A effective to ameliorate at least one symptom or clinical sign of the condition.

Inventors: Charles Melancon, Pamela Hall, Jacob Greenberg, Yasushi Ogasawara, Snežna Rogelj

Antibiotic sensitivity-restoring and photosensitive agents

Patent number: 9834514

Abstract: The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.

Inventors: Snežna Rogelj, Liliya Frolova, Alexander Kornienko, Leslie D. Edwards, Cody Champion, Kailee Zingler, Danielle Nicole Turner

Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and method of producing same

Patent number: 9334280

Abstract: A compound having the Formula as follows: wherein R, R1 and R2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated carbocylclic, partially saturated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, C1-10 alkyl, haloalkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, alkenylalkyl, alkynylalkyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, and acyloxyalkyl. A process for the preparation thereof is also provided.

Inventors: Igor V. Magedov, Snežna Rogelj, Liliya V Frolova, Alexander Vladimir Kornienko

Treatment of drug-resistant cancer with 2-aryl-2-(3-indolyl) acetohydroxamates

Patent number: 9206124

Abstract: A pharmaceutical composition, a method of producing same, and a method of providing cancer therapy therein comprising a pharmaceutically acceptable excipient or carrier and a compound Formula 3 as follows: or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1, R2, R3 and R4 are optionally substituted and are hydrogen, haloalkyl, aryl, fused aryl, carbocyclic, a heterocyclic group, a heteroaryl group, C1-10 alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, acyloxyalkyl, hydroxyl, alkoxy, acetoxy, amino, alkylamino, acetamido.

Inventors: Alexander V. Akensov, Snežna Rogelj, Liliya Frolova, Alexander Kornienko, Gabriel Avilucea

Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and method of producing same

Patent number: 8946246

Abstract: A compound having the Formula I as follows: wherein R1 and R2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated carbocylclic, partially saturated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, C1-10 alkyl, haloalkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, and acyloxyalkyl. A process for the preparation thereof is also provided.

Inventors: Igor V. Magedov, Snežna Rogelj, Liliya Vladlenovna Frolova, Alexander Vladimir Kornienko

Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof

Patent number: 8349864

Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient or carrier and a compound Formula I: or a pharmaceutically acceptable salt or prodrug thereof.

Inventors: Alexander Kornienko, Igov V. Magedov, Snežna Rogelj

Inhibition of cell surface protein disulfide isomerase

Patent number: 6949665

Abstract: The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce

Inventors: Snežna Rogelj, Larry A. Sklar, Robert B. Palmer

Method for induction of L-selectin shedding

Patent number: 6943268

Abstract: The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding.

Method for induction of L-selectin shedding

Patent number: 6498189

Inventors: Snežna Rogelj, Teresa A. Bennett, Larry A. Sklar

Publications List

Peer-reviewed Publications

[1] S. Rogelj, B. Loewy and R.M. Niles: The Effect of Retinoic Acid on Cyclic AMP Binding Proteins in Mouse Melanoma Cells. European Journal of Biochemistry 139: 351-357 (1984).

[2] R.M. Niles, B. Loewy and S. Rogelj: The Effect of Retinoic acid on Protein Phosphorylation in Mouse Melanoma Cells. Experimental Cell Research 164: 437-44 (1986).

[3] S.H. Friend, R. Bernards, S. Rogelj, R.A. Weinberg, J.M. Rappaport, D.M. Albert and T.P. Dryja: Identification of a Human DNA Segment Having Properties of the Gene that Predisposes to Retinoblastoma and Osteosarcoma. Nature, 323(6089): 643-646 (1986).

[4] S. Rogelj, R.A. Weinberg, P. Fanning and M. Klagsbrun: Basic Fibroblast Growth Factor (bFGF) Fused to a Signal Peptide Transforms Cells. Nature, 331(6152): 173-175 (1988).

[5] R. Hannan, S. Kourembans, K. Flanders, S. Rogelj, A. Roberts, D. Faller and M. Klagsbrun: Human Endothelial Cells Synthesize Fibroblast Growth Factor and Transforming Growth Factor Beta. Growth Factors, 1: 7-17 (1988).

[6] S. Rogelj, R.A. Weinberg, P. Fanning and M. Klagsbrun: Characterization of Tumors Produced by Signal Peptide-bFGF Transformed Cells. Journal of Cellular Biochemistry 39: 13-24(1989).

[7] S. Rogelj, M. Klagsbrun, R. Atzmon, M. Kurokawa, A.Haimovitz, Z. Fuks and I. Vlodavsky: Basic fibroblast growth required for supporting the proliferation of vascular endothelial cells and the differentiation of PC-12 cells. Journal of Cell Biology, 109: 823-831 (1989).

[8] N. Iberg, S. Rogelj, P. Fanning and M. Klagsbrun: Purification of 18 kDa and 22 kDa forms of basic fibroblast growth factor in cells transformed by the ras oncogene. Journal of Biological Chemistry, 264 (33): 19951-19955 (1989).

[9] S.E. Egan, L. Jarolim, S. Rogelj, M. Spearman, J.A. Wright and A.H. Greenberg: Growth Factor Modulation of Metastatic Lung Colonization. Anticancer Research 10: 1341-1346 (1990).

[10] W.E.Serafin, D.S.Reynolds, S.Rogelj, W.S.Lane, G.Conder, S.S.Johnson, K.F.Austen and

R.L.Stevens: Identification and Molecular Cloning of a Novel Mouse Mucosal Mast Cell Serine Protease. Journal of Biological Chemistry 265(1): 423-429 (1990).

[11] Goldstein B., Rogelj S., Siegal S., Farmer S.R., Niles R.M.: Cyclic AMP mediated induction of F9 teratocarcinoma differentiation in the absence of retinoic acid. Journal of Cellular Physiology 143

(2):205-212 (1990).

[12] Bennett T.A., Schammel C.M.G., Lynam E.B., Guyer D.A., Mellors A., Edwards B., Rogelj S. and Sklar L.A.: Evidence for a third component in neutrophil aggregation: potential roles of O-linked glycoproteins as L-selectin counter-structures Journal of Leukocyte Biology 58: 510-518 (1995).

[13] Bennett T.A., E.B. Lynam, Sklar L.A. and Rogelj S.: Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation. Journal of Immunology 156: 3093-3097 (1996).

[14] Lynam E.B., Rogelj S., Edwards, B.S. and Sklar, L.A.: Enhanced aggregation in human neutrophils by MnCl2 or DTT differentiates the roles of L-selectin and beta2 integrins. Journal of Leukocyte Biology 60: 356-364, (1996).

[15] Guyer D.A., Moore K., Schammel C.M.G., Lynam E., Bennett T., Rogelj S, Edwards B.S., Mellors A., McEver R., and Sklar, L.A.: P-Selectin Glycoprotein Ligand-1(PSGL-1) is a Ligand for L-selectin in Neutrophil Aggregation. Blood 88:(7) 2415-2421 (1996).

[16] Bennett T.A., Edwards,B.S., Sklar L.A. and Rogelj S.: Sulfhydryl Regulation of L-Selectin: Promotion of Activation Independent L-selectin Shedding from Leukocytes. Journal of Immunology 164:4120-4129 (2000).

[17] Rogelj S., Reiter K.J., Kesner L., Li M. and Essex D.: Enzyme Destruction by a Protease

Contaminant in Bacitracin. Biochemical and Biophysical Research Communications. 273(3):829-832 (2000).

[18] Liang H., Cordova SE., Kieft TL., Rogelj S. "A highly sensitive immuno-PCR assay for detecting Group A Streptococcus" Journal of Immunological Methods. 279(1-2):101-10 (2003).

[19] Fu, Z., S. Rogelj, and T. L. Kieft "Detection of Escherichia coli O157:H7 by immuno-magnetic separation and real-time PCR" International Journal of Food Microbiology. 99: 47-57 (2005).

[20] Shen K., Curran S., Xu H., Rogelj S., Jiang Y., Dewald J., and Pietrab T. "Single-walled carbon nanotube purification, pelletizing and surfactant-assisted dispersion: A combined TEM and resonant micro-Raman spectroscopy study". The Journal of Physical Chemistry B. 109:4455-4463 (2005).

[21] Shen, H., Rogelj, S., and T. L. Kieft "Sensitive, Real-time PCR Detects Low-levels of Contamination by Legionella pneumophila in Commercial Reagents". Molecular and Cellular Probes. 20(3-4):147-153 (2006).

[22] Allen R.C.; Rogelj, S., Cordova, S.E., and T. L. Kieft. "An Immuno-PCR Method for Detecting Bacillus thuringiensis Cry1Ac Toxin" Journal of Immunological Methods. 20(3-4): 147-153 (2006).

[23] A. S. Kireev, O. N. Nadein, V. J. Agustin, N. E. Bush, A. Evidente, M. Manpadi, M. A. Ogasawara, S. K. Rastogi, S. Rogelj, S.T. Shors, A. Kornienko. "Synthesis and Biological Evaluation of Aromatic Analogues of Conduritol F, L-chiro-Inositol and Dihydroconduritol F Structurally Related to the Amaryllidaceae Anticancer Constituents" Journal of Organic Chemistry 71, 5694-5707 (2006).

[24] Zhang P, S. Rogelj, K. Nguyen, and D. Wheeler. Design of a Highly Sensitive and Specific Nucleotide Sensor Based on Photon Upconverting Particles. JACS 128 (38), 12410 -12411 (2006).

[25] Magedov, I. V.; Manpadi, M.; Rozhkova, E.; Przheval'skii, N. M.; Rogelj, S.; Shors, S. T.; Steelant, W. F. A.; Van slambrouck, S. and A. Kornienko. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis: Dihydropyridopyrazole Analogues of Podophyllotoxin. Bioorganic and Medicinal Chemistry Letters 17, 1381-1385 (2007).

[26] Magedov, I. V.; Manpadi, M.; Evdokimov, N. M.; Elias, E. M.; Rozhkova, E.; Ogasawara, M. A.; Bettale, J. D.; Przeval'skii, N. M.; Rogelj, S.; Kornienko, A. Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis. Bioorganic and Medicinal Chemistry Letters 17, 3872-3876 (2007).

[27] Magedov, I.V.; Manpadi, M.; Van Slambrouck, S.; Steelant, W. F. A.; Rozhkova, E.; Przhevaliskii, N. M.; Rogelj, S.; Kornienko, A. Discovery and Investigation of Antiproliferative and Apoptosis-Inducing Properties of New Heterocyclic Podophyllotoxin Analogues Accessible by a One-Step Multicomponent

Synthesis. Journal of Medicinal Chemistry 50, 5183-5192 (2007).

[28] Manpadi, M.; Uglinskii, P. Y.; Rastogi, S. K.; Cotter, K. M.; Wong, Y-S. C.; Anderson, L. A.; Ortega, A. J.; Van slambrouck, S.; Steelant, W. F. A.; Rogelj, S.; Tongwa, P.; Antipin, M. Y.; Magedov, I. V.; Kornienko, A. Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties. Organic & Biomolecular Chemistry . 5, 3865 - 3872 (2007).

[29] Magedov, I. V.; Manpadi, M.; Ogasawara, M. A.; Dhawan, A. S.; Rogelj, S.; Van slambrouck, S.; Steelant, W. F. A.; Evdokimov, N. M.; Uglinskii, P. Y.; Elias, E. M.; Knee, E. J.; Tongwa, P.; Antipin, M. Y.; Kornienko, A. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones. Journal of Medicinal Chemistry 51, 2561-2570 (2008).

[30] Guo Y., Rogelj S. and Zhang, P. Rose Bengal-decorated silica nanoparticles as photosensitizers for inactivation of gram-positive bacteria. Nanotechnology. 21 (2010) 065102. doi:10.1088/0957-4484/21/6/065102.

[31] Tang, H., Zhang, P., Kieft, T.L., Ryan, S.J., Baker, S.M., Wiesmann, W.P., Rogelj, S.

Antibacterial action of a novel functionalized chitosan-arginine against gram-negative bacteria, Acta Biomaterialia 6(7) 2562-2571 (2010).

[32] Evdokimov, N. M.; Van slambrouck, S.; Heffeter, P.; Tu, L.; Le Calve, B.; Lamoral-Theys, D.; Hooten, C. J.; Uglinskii, P. Y.; Rogelj, S.; Kiss, R.; Steelant, W. F. A.; Berger, W.; Yang, J. J.; Bologa, C. J.; Kornienko, A.; Magedov, I. V. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused Uracil-Containing Heterocycles as Novel Topoisomerase-Targeting Agents. Journal of Medicinal Chemistry 54, 2012 -2021 (2011).

[33] Frolova, L. V.; Evdokimov, N. M.; Hayden, K.; Malik, I.; Rogelj, S.; Kornienko, A.; Magedov, I. V. One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A short General Synthesis of Rigidins A, B, C, and D. Organic Letters. 13, 1118-1121 (2011).

[34] Magedov, I.; Frolova, L.; Manpadi, M.; Bhoga, U.; van Otterlo, W.; Tang, H.; Evdokimov, N.; George, O.; Hadji Gorgeou, K.; Renner, S.; Getlik, M.; Kinnibrugh, T.; Fernandes, M.; Van slambrouck, S.; Shuster, C.; Rogelj, S.; Steelant, W.; Kornienko, A.: Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis. Journal of Medicinal Chemistry. 54(12):4234-4246 (2011).

[35] Seth Daly , Kathryn Hayden, Indranil Malik, Nikki Porch, Hong Tang, Snezna Rogelj, Liliya V. Frolova, Katrina Lepthien, Alexander Kornienko, and Igor V. Magedov.: Unprecedented C-2 Arylation of Indole with Diazonium Salts: Syntheses of 2,3-Disubstituted Indoles and their Antimicrobial Activity. Bioorganic & Medicinal Chemistry Letters 21(16) 4720-4723 (2011).

[36] Liliya V. Frolova, Nikolai M. Evdokimov, Kathryn Hayden, Indranil Malik, Snezna Rogelj, Alexander Kornienko, and Igor V. Magedov One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A Short General Synthesis of Rigidins A, B, C, and D. Organic Letters 13 (5), 1118-1121 (2011).

[37] L. V. Frolova, N. M. Evdokimov, K. Hayden, I. Malik, S. Rogelj, A. Kornienko, I. V. Magedov: Synthesis of Polysubstituted 2-Aminopyrroles via a Multicomponent Reaction. Organic Letters 13, 1118-1121 (2011).

[38] Frolova LV, Malik I, Uglinskii PY, Rogelj S, Kornienko A, Magedov IV.: Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity. Tetrahedron Lett. 7;52(49):6643-6645 (2011).

[39] G. Luchetti, R. Johnston, V. Mathieu, F. Lefranc, K.Hayden, A. Andolfi, D. Lamoral-Theys, M. R. Reisenauer, C.Champion, S.C. Pelly, W. A. L. van Otterlo, I. V. Magedov, R. Kiss, A.Evidente, S. Rogelj, and A. Kornienko.: Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity towards Apoptosis-Resistant Glioma Cells. ChemMedChem. 7(5) 815-822 (2012).

[40] I. Magedov, N. Evdokimov, M. Karki, A. Peretti, D. Lima, L. Frolova, M. Reisenauer, A.Romero, P. Tongwa, A. Fonari, J. Altig, S. Rogelj, M. Antipin, C. Shuster, A. Kornienko: Reengineered Epipodophyllotoxin. Chemical Communications. 48, 10416-10418 (2012).

[41] Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J Extracellular protein disulfide isomerase regulates ligand binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood. 9;121(19):3789-800 (2013).

[42] [Batyeva ES, EK Badeeva, E V Platova, AT Gubaidullin, N Porch, L Edwards, I Malik, LV Frolova, IV Magedov, S Rogelj and OG Sinyashin. Green Chemistry. Reaction of Elemental Phosphorus (P4) and Elemental Sulfur with Protonodonor Reagents: New Methods for the Synthesis of Ammonium Salts of S,S'-Dialkyltetrathiophosphoric Acids and Octathiotetraphosphetane Heteroatom Chemistry, 03/19/2013, DOI: 10.1002/hc.21077 (2013).

[43] Magedov IV, F Lefranc, LV Frolova, L Moreno Y. Banuls, AS Peretti, S Rogelj , V Mathieu, R Kiss, A Kornienko. Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells. Bioorganic & Medicinal Chemistry Letters, 23 (11), pp 3277-3282 (2013).

[44] Frolova LV, IV Magedov, AE Romero, M Karki, I Otero, K Hayden, NM Evdokimov, L Moreno Y Banuls, SK Rastogi, WR Smith, S-L Lu, R Kiss, CB Shuster, E Hamel, T Betancourt, S Rogelj, A Kornienko. Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids. Journal of Medicinal Chemistry. 56 (17), pp 6886-6900 (2013).

[45] Scott R, Karki M, Reisenauer MR, Rodrigues R, Dasari R, Smith WR, Pelly SC, van Otterlo WA, Shuster CB, Rogelj S, Magedov IV, Frolova LV, Kornienko A. Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins. ChemMedChem. 9 (7): 1428-1435 (2014)

[46] Kursheva L, N. V. Yanberdina, E. E. Zvereva, A. E. Vandyukov, M. R. Reisenauer, J. D. Lujan, R. W. Lebrun, L. D. Edwards, S. Rogelj, L. V. Frolova, E. S. Batyeva, O. G. Sinyashin. Synthesis and Some Properties of Transition Metal Complexes Based on the Octathiophophetane Ammonium Salts. Heteroatom Chemistry 06/05/2014; DOI:10.1002/hc.21152 (2014)

[47] Tello-Aburto R, AN Lucero, S Rogelj. A catalytic approach to the MH-031 lactone: application to the synthesis of geralcin analogs. Tetrahedron Letters 55 (45) pp, 6266-6268 (2014)

[48] Margaret Snell, Anwar M. Hossain, Oleg Makhnin, and Snezna Rogelj. Inverse associations between parabens and obesity/diabetes in adults. Global Journal of Quantitative Science Vol. 1. No.4. Issue, pp.1-7 (2014)

[49] Vshyvenkoa S, M. R. Reisenauer, S. Rogelj, T. Hudlicky: Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide Bioorganic & Medicinal Chemistry Letters, 24 (17), pp 4236-4238 (2014)

[50] M. Masi, L. V. Frolova, X.Yud, V. Mathieu, A. Cimmino, A.De Carvalho, R. Kiss, S. Rogelj, A. Pertsemlidis, A. Kornienko, A. Evidente. Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer. Fitoterapia 102: 41-48 (2015)

[51] R. Johnston, S. Rogelj, J. C. Harper and M. Tartis. Sol-Generating Chemical Vapor into Liquid (SGCViL) deposition - a facile method for encapsulation of diverse cell types in silica matrices. J. Mater. Chem. B, 3,1032 (2015).

[52] A. V. Aksenov, A. N. Smirnov, I. V. Magedov, M. R. Reisenauer, N. A. Aksenov, I. V. Aksenova, A. L. Pendleton, G. Nguyen, R. K. Johnston, M.Rubin, A. De Carvalho, R.Kiss, V. Mathieu, F. Lefranc, J. Correa, D. A. Cavazos, A. J. Brenner, B. A. Bryan, S. Rogelj, A.Kornienko, and L. V. Frolova. Activity of 2- Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells. Journal of Medicinal Chemistry. 2015, 58, 2206-2220 (2015).

[53] Y. Ogasawara, B. J. Yackley, J. A. Greenberg, S. Rogelj, C. E. Melancon III. Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics- Guided Identification of Frankiamicin A from Frankia sp. EAN1pec. PLOS ONE DOI:10.1371/journal.pone.0121505 April 2 (2015).

[54] Tello-Aburto, Rodolfo, Liam P. Hallada, Doleshwar Niroula, Snezna Rogelj . "Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B." Organic & Biomolecular Chemistry 13.40: 10127-10130 (2015).

[55] Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines. European Journal of Medicinal

Chemistry 103 (2015): 226-237. (2015)

[56] Ramesh Dasari, Annelise De Carvalho, Derek C Medellin, Kelsey N Middleton, Frederic Hague, Marie N M Volmar, Liliya V Frolova, Mateus F Rossato, Jorge J De La Chapa, Nicholas F Dybdal-Hargreaves, Akshita Pillai, Veronique Mathieu, Snezna Rogelj, Cara B Gonzales, Joao B Calixto, Antonio Evidente, Mathieu Gautier, Gnanasekar Munirathinam, Rainer Glass, Patricia Burth, Stephen C Pelly, Willem A L van Otterlo, Robert Kiss, Alexander Kornienko. Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.

ChemMedChem doi: 10.1002/cmdc.201500360. (2015)

[57] Derek C. Medellin, Qiong Zhou, Robert Scott, R. Matthew Hill, Sarah K. Frail, Ramesh Dasari, Steven J. Ontiveros, Stephen C. Pelly, Willem A. L. van Otterlo, Tania Betancourt, Charles B. Shuster, Ernest Hamel, Ruoli Bai, Daniel V. LaBarbera, Snezna Rogelj, Liliya V. Frolova, and Alexander Kornienko Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. Journal of Medicinal Chemistry (2016) 59 (1), 480-485. DOI: 10.1021/acs.jmedchem.5b01426 (2016)

[58] Badeeva, Elena K., Angelo Santomenna, Aidar T. Gubaidullin, Liliya V. Frolova, Snezna Rogelj, Elvira S. Batyeva, and Oleg G. Sinyashin. New method for the synthesis of ammonium salts of O, O'-alkylenedithiophosphoric acid and octathiotetraphosphetane. Crystal structure features's of diethylammonium salt of O, O'-propylenedithiophosphoric acid. Phosphorus, Sulfur, and Silicon and the Related Elements 191, no.3: 405-410. (2016)

[59] Henry, Sean, Ria Kidner, Mary R. Reisenauer, Igor V. Magedov, Robert Kiss, Veronique Mathieu, Florence Lefranc et al. 5, 10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells. European Journal of Medicinal Chemistry 120: 313-328. (2016)

[60] Doleshwar Niroula, Liam Halada, Snezna Rogelj, Rodolfo Tello-Aburto. A total synthesis of (-)- hortonone C Tetrahedron 73(4) 359-364 (2016)

[61] E. S. Batyeva, E. K. Badeeva, O. G. Sinyashin, I. S. Nizamov, L. V. Frolova, S. Rogelj, and L. I. Kurcheva Octathiotetraphosphetanes-Novel class of biologically active phosphorusorganic compounds: Synthesis, structure, properties Phosphorus, Sulfur, and Silicon and the Related Elements 191:1642-1642 (2016)

[62] Maxwell Baymiller, Frank Huang, Snezna Rogelj. Rapid one-step synthesis of gold nanoparticles using the ubiquitous coenzyme NADH. Matters (ISSN: 2297-8240) DOI:

10.19185/matters.201705000007 (2017)

[63] Desymmetrization of Cyclopropenes via the Potassium-Templated Diastereoselective 7-exo-trig Cycloaddition of Tethered Amino Alcohols toward Enantiopure Cyclopropane-Fused Oxazepanones with Antimycobacterial Activity.Maslivetc, Vladimir A; Turner, Danielle N; McNair, Kimberly N; Frolova, Liliya; Rogelj, Snežna; Maslivetc, Anna A; Aksenov, Nicolai A; Rubina, Marina; Rubin, Michael; The Journal of organic chemistry. 83 (10):5650-5664 (2018)

[64] Fate, transformation, and toxicological impacts of pharmaceutical and personal care products in surface waters Maldonado-Torres, Sabino; Gurung, Rubi; Rijal, Hom; Chan, Andrew; Acharya, Shishir; Rogelj, Snežna; Piyasena, Menake; Rubasinghege, Gayan. Environmental health insights 12, 1178630218795836 (2018)

[65] Abiotic degradation and environmental toxicity of ibuprofen: Roles of mineral particles and solar radiation. Rubasinghege, Gayan; Gurung, Rubi; Rijal, Hom; Maldonado-Torres, Sabino; Chan, Andrew; Acharya, Shishir; Rogelj, Snežna; Piyasena, Menake. Water research 131:22-32 (2018)

[66] Metal-templated assembly of cyclopropane-fused diazepanones and diazecanones via exo-trig nucleophilic cyclization of cyclopropenes with tethered carbamates. Maslivetc, Vladimir A; Frolova, Liliya V; Rogelj, Snežna; Maslivetc, Anna A; Rubina, Marina; Rubin, Michael. The Journal of organic chemistry 83(22):13743-13753 (2018)

[67] Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes. Turner, Danielle N; Just, Jeremy; Dasari, Ramesh; Smith, Jason A; Bissember, Alex C; Kornienko, Alexander; Rogelj, Snežna. Natural product research. 1-4 (2019)

[68] Spectroscopic Study of a Photoactive Antibacterial Agent: 2, 3-Distyrylindole.Rajapaksha, Ruwini D; Banet, Matthias; Champion, Cody; Frolova, Liliya V; Rogelj, Snežna; Choudhury, Pabitra; Ranasinghe, Mahinda I. The Journal of Physical Chemistry A 122(4):937-945 (2018)

[69] Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multi-Drug Resistance Proteins. Ramesh Dasari, Andrzej Błauż, Derek C Medellin, Roaa M Kassim, Carlos Viera, Maximo Santarosa, Danielle Turner, Alet E van der Westhuyzen, Willem AL van Otterlo, Taryn Olivas, Tugba Yildiz, Tania Betancourt, Charles B Shuster, Snežna Rogelj, Błażej Rychlik, Todd Hudnall, Liliya V Frolova, Alexander Kornienko. ChemMedChem 14(3)322 (2019)

[70] Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors. Niroula, Doleshwar; Hallada, Liam P; Le Chapelain, Camille; Ganegamage, Susantha K; Dotson, Devon; Rogelj, Snežna; Groll, Michael; Tello-Aburto, Rodolfo. European journal of medicinal chemistry 157: 962-977 (2018)

[71] Photoactivated 2, 3-distyrylindoles kill multi-drug resistant bacteria. Edwards, Leslie; Turner, Danielle; Champion, Cody; Khandelwal, Megha; Zingler, Kailee; Stone, Cassidy; Rajapaksha, Ruwini D; Yang, Jing; Ranasinghe, Mahinda I; Kornienko, Alexander; Bioorganic & medicinal chemistry letters 28(10): 1879-1886 (2018)

[72] Photo-physical properties of substituted 2, 3-distyryl indoles: Spectroscopic, computational and biological insights. Rajapaksha, Ruwini D; Turner, Danielle N; Vigil, Jade; Frolova, Liliya V; Altig, Jeffrey A; Rogelj, Snežna; Ranasinghe, Mahinda I. Journal of Photochemistry and Photobiology A: Chemistry 376:73-79 (2019)

[73] A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications. Ellepola, Nishanthi; Ogas, Talysa; Turner, Danielle N; Gurung, Rubi; Maldonado-Torres, Sabino; Tello-Aburto, Rodolfo; Patidar, Praveen L; Rogelj, Snežna; Piyasena, Menake E; Rubasinghege, Gayan; Ecotoxicology and environmental safety 188: 109892 (2020)

[74] Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria. Turner, Danielle N; Edwards, Leslie; Kornienko, Alexander; Frolova, Liliya V; Rogelj, Snežna; Future Microbiology 15(8):579-590 (2020)

[75] Effects of physiological deficits in pineal melatonin on Triple Negative Breast Cancer. Dearing, Carley G; Silva, Primal D; Turner, Danielle N; Fish, Betty A; Contreras, Ethan O; Schwarting, Zuri A; Sena, Johnny; Schilkey, Faye D; Bearer, Elaine L; Wilkinson, Stephen D; Snežna Rogelj, Stewart Thompson. BioRxiv (2020)

Selected Book Contributions

[1] S. Rogelj and M. Klagsbrun: Basic Fibroblast Growth Factor Induces Tumorigenicity in Immunocompetent Animals Only After Acquiring a Signal Peptide. Progress in Endocrinology, 517-522. Imura et al., editors. Elsevier Science Publishers B.V., Biomedical Division, 1988.

[2] S. Rogelj and M. Klagsbrun: Oncogenic Transformation by Basic Fibroblast Growth Factors. In: Paracrine and Autocrine Factors in Reproductive Endocrinology, p.19-28. Bela J. Gulyas and Lewis C. Krey, eds. Plenum Press, 1989.

[3] M. Klagsbrun, P. Fanning and S. Rogelj: Ras Transformation in 3T3 cells induces fibroblast growth factor synthesis in vitro and in vivo. In: Molecular Mechanisms in Cellular Growth and Differentiation. P&S Biomedical Sciences Symposia, 1989.

[4] S. Rogelj, D.F. Stern and M. Klagsbrun: Construction and Expression of a Transforming Gene Resulting From a Fusion of a Basic FGF Gene with a Signal Peptide Sequence. In: Peptide Growth Factors, Methods in Enzymology, 198 , 117-124. D. Barnes, J.P. Mather and G.H. Sato, eds. Academic Press, 1991.